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Graham J Atwell Selected Research

nitromide (Unistat)

3/2010Metabolism and excretion of the novel bioreductive prodrug PR-104 in mice, rats, dogs, and humans.
7/2007Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104.

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Graham J Atwell Research Topics

Disease

7Neoplasms (Cancer)
02/2014 - 06/2004
6Hypoxia (Hypoxemia)
08/2011 - 07/2007
1Leukemia
02/2014
1Prostatic Neoplasms (Prostate Cancer)
09/2012
1Hypersensitivity (Allergy)
06/2009

Drug/Important Bio-Agent (IBA)

6ProdrugsIBA
08/2011 - 07/2007
6DNA (Deoxyribonucleic Acid)IBA
08/2011 - 07/2007
4Oxidoreductases (Dehydrogenase)IBA
03/2011 - 02/2008
4PR-104IBA
03/2011 - 07/2007
3Aldo-Keto ReductasesIBA
02/2014 - 03/2011
3Alkylating AgentsIBA
08/2011 - 11/2009
3PR-104AIBA
03/2011 - 07/2007
3Hydroxylamine (Hydroxylamine Hydrochloride)IBA
03/2011 - 07/2007
2DuocarmycinsIBA
08/2011 - 03/2011
2Phosphates (Orthophosphate)IBA
03/2011 - 03/2010
2AminesIBA
03/2011 - 03/2010
2nitromide (Unistat)IBA
03/2010 - 07/2007
2Mechlorethamine (Nitrogen Mustard)FDA Link
03/2010 - 07/2007
1EnzymesIBA
02/2014
1Hormones (Hormone)IBA
02/2014
1Protein Isoforms (Isoforms)IBA
09/2012
1AcidsIBA
09/2012
1Naproxen (Naprosyn)FDA LinkGeneric
03/2011
1EstersIBA
03/2010
1Chlorambucil (Leukeran)FDA Link
06/2009
1Mitomycin (Mitomycin-C)FDA LinkGeneric
06/2009
1Cytotoxins (Cytolysins)IBA
02/2008
1GemcitabineFDA Link
07/2007
1Tirapazamine (SR 4233)IBA
07/2007
1Docetaxel (Taxotere)FDA Link
07/2007
1tretazicarIBA
06/2004

Therapy/Procedure

2Therapeutics
07/2010 - 11/2009
1Radiotherapy
07/2007
1Drug Therapy (Chemotherapy)
07/2007
1Aftercare (After-Treatment)
07/2007